Biomembranes and Bioenergetics
Life Sciences (School of)
Undergraduate: Level 6
Thursday 03 October 2019
Saturday 14 December 2019
25 March 2019
Requisites for this module
BSC C700 Biochemistry,
BSC C701 Biochemistry (Including Placement Year),
BSC C703 Biochemistry (Including Year Abroad),
BSC CR00 Biochemistry (Including Foundation Year)
Biomembranes are of fundamental importance in determining the organisation and functioning of living cells. Biophysical and biochemical methods to study membranes will be discussed alongside the specific roles of membranes in the signal transduction, ion and solute transport and energy storage in cells.
Energy generation and transformation by membranes is an essential feature of all cells: membrane electron transport processes will be discussed (with particular attention being given to respiratory and photosynthetic processes), together with the chemiosmotic theory for ATP synthesis by membranes. A bottom up approach building from basic thermodynamics to observed macroscopic effects and biological function is taken. Particular emphasis is placed on the quantitative description of chemical free energy changes and electron transfer reactions allowing students to analyse and interpret biophysical data in the context of actual experiments.
The aims of this course are to introduce students to basic composition and biophysical properties of biomembranes and how they are associated with cellular activities. The second focus of the course is on the principles underpinning energy transduction and storage by biomembranes and the role of electrochemical gradients in cellular function.
These aims will be explored in the context of lipid and membrane protein structure and how it translates into the activity of biological membranes.
In order to pass this module, students will need to be able to:
1. Describe the structure, organisation and biogenesis of biological membranes. Explain how physico-chemical properties of the lipids and proteins lead to the dynamic nature of biological membranes;
2. Have comprehensive knowledge of the main characteristics of membrane proteins and their roles in membrane structure, transport and signaling;
3. Demonstrate deep and rational understanding of how ions and solutes are transported across biological membranes, thus creating membrane gradients; demonstrate ability to solve practical problems related to membranes;
4. Explain the principles of photosynthetic energy conversion and chemiosmotic theory of energy transduction by biological membranes;
5. Demonstrate critical understanding of the thermodynamics underpinning these mechanisms;
6. Demonstrate comprehensive knowledge of the range of methods and techniques used to study membranes, apply equations in analysis and interpretation of complex biophysical data.
Employability and transferrable skills:
7. Advance knowledge of the theory and practice of key techniques used in lipid and membrane protein research.
8. Solid understanding of the theory and practical aspects of thermodynamics and kinetics.
9. Ability to demonstrate competence in data presentation, analysis and interpretation (DAI). Work effectively as part of a team to analyse and present experimental and theoretical data.
10. Ability to read and analyse scientific literature and use online information retrieval services –e.g. Pubmed.
11. Time management – self-directed study – prioritising.
The School has a policy which ensures all lecturers opt-in to making lectures available via Listen Again. Therefore, in teaching rooms where the facility is available, lectures will be recorded via this service.
No additional information available.
Lectures: 18 hours
Revision workshop: 2 hours
- Nicholls, David G.; Ferguson, Stuart J. (2013) Bioenergetics 4, Amsterdam: Academic Press.
- Alberts, Bruce; Johnson, Alexander; Lewis, Julian; Morgan, David; Raff, Martin; Roberts, Keith; Walter, Peter; Wilson, John; Hunt, Tim. (2015) Molecular biology of the cell, New York, NY: Garland Science, Taylor and Francis Group.
The above list is indicative of the essential reading for the course. The library makes provision for all reading list items, with digital provision where possible, and these resources are shared between students. Further reading can be obtained from this module's reading list.
Module supervisor and teaching staff
Dr Vassily Bavro, Dr Dima Svistunenko
School Undergraduate Office, email: bsugoffice (Non essex users should add @essex.ac.uk to create the full email address)
No external examiner information available for this module.
Available via Moodle
Of 30 hours, 27 (90%) hours available to students:
3 hours not recorded due to service coverage or fault;
0 hours not recorded due to opt-out by lecturer(s).
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