BS221-5-AU-CO:
Molecular Biology: Genes, Proteins and Disease

The details
2023/24
Life Sciences (School of)
Colchester Campus
Autumn
Undergraduate: Level 5
Current
Thursday 05 October 2023
Friday 15 December 2023
15
07 August 2023

 

Requisites for this module
(none)
(none)
(none)
(none)

 

BS312, BS320

Key module for

BSC C700 Biochemistry,
BSC C701 Biochemistry (Including Placement Year),
BSC C703 Biochemistry (Including Year Abroad),
BSC CR00 Biochemistry (Including Foundation Year),
BSC B990 Biomedical Science,
BSC B991 Applied Biomedical Science (NHS placement),
BSC B995 Biomedical Science (Including Year Abroad),
BSC B999 Biomedical Science (Including Placement Year),
BSC BD00 Biomedical Science (Including Foundation Year),
MSCIB099 Biomedical Science,
MSCIBA99 Biomedical Science (Including Placement Year),
MSCIBB99 Biomedical Science (Including Year Abroad),
BSC C400 Genetics,
BSC C402 Genetics (Including Year Abroad),
BSC C403 Genetics (Including Placement Year),
BSC CK00 Genetics (Including Foundation Year),
BSC C110 Biotechnology,
BSC C111 Biotechnology (Including Foundation Year),
BSC C112 Biotechnology (Including Year Abroad),
BSC C113 Biotechnology (Including Placement Year),
MSCIC114 Biotechnology,
BSC C200 Human Biology,
BSC C201 Human Biology (Including Year Abroad),
BSC C202 Human Biology (Including Placement Year),
BSC C220 Human Biology (Including Foundation Year),
MSCIC098 Biochemistry and Biotechnology (Including Year Abroad),
MSCIC099 Biochemistry and Biotechnology (Including Placement Year),
MSCICZ99 Biochemistry and Biotechnology

Module description

This module explores the breadth of processes involved in the expression of eukaryote genes, including the latest techniques used in molecular biology with an emphasis on genetic engineering and the production of therapeutic proteins.


The process of gene expression begins with the regulatory proteins that combine to assemble the transcriptional machinery at the promoter of a gene, followed by the processing and turnover of RNA transcripts. We move on to address the processes of protein synthesis, protein folding and the post-transcriptional modification of proteins.

Module aims

The aim of this module is:



  • To explore the breadth of processes involved in the expression of eukaryote genes, including the latest techniques used in molecular biology with an emphasis on genetic engineering and the production of therapeutic proteins.

Module learning outcomes

By the end of this module, students will be expected to be able to:



  1. Describe the structural organisation of the gene and associated regulatory sequences.

  2. Explain the process of transcription and the regulation of gene expression.

  3. Describe how proteins are synthesized, targeted and degraded in cells.

  4. Understand a range of molecular biology techniques including PCR, cloning, mutagenesis and protein expression.

  5. Demonstrate competence in a) The analysis and interpretation of data, b) Written communication and practical DNA manipulation techniques.

Module information

Molecular biology is central to nearly all aspects of our knowledge of how biology "works" at a molecular level. Throughout this module, there will be an emphasis on the impact of disease on these processes and opportunity for treatment presented by applying an understanding of the molecular biology.


Syllabus



  • Practical class I:

    • Introduction to BioBricks (PC lab).

    • Design, digest, and ligate DNA in silico to visualise synthetic biology (SynBio) cloning methods.

    • Design a novel biosensor using BioBricks.



  • Practical class II:

    • Restriction digest, ligation, and transformation to create clones of multicoloured bacteria.



  • Practical class III:

    • Purify and analyse a fluorescent (GFP-tagged) protein.



Learning and teaching methods

This module will be delivered via:

  • One 1-hour lecture per week.
  • Two 2-hour PC practicals.
  • Two 3-hour practicals.

Bibliography

The above list is indicative of the essential reading for the course.
The library makes provision for all reading list items, with digital provision where possible, and these resources are shared between students.
Further reading can be obtained from this module's reading list.

Assessment items, weightings and deadlines

Coursework / exam Description Deadline Coursework weighting
Coursework   Molecular Mechanisms    5% 
Coursework   Prac 1: SynBio    20% 
Coursework   Gene Expression    15% 
Coursework   Post-Transc Regulation    5% 
Coursework   Prac 3: GFP Protein    25% 
Coursework   Prac 2: Biosensor Worksheet   01/12/2023  30% 

Exam format definitions

  • Remote, open book: Your exam will take place remotely via an online learning platform. You may refer to any physical or electronic materials during the exam.
  • In-person, open book: Your exam will take place on campus under invigilation. You may refer to any physical materials such as paper study notes or a textbook during the exam. Electronic devices may not be used in the exam.
  • In-person, open book (restricted): The exam will take place on campus under invigilation. You may refer only to specific physical materials such as a named textbook during the exam. Permitted materials will be specified by your department. Electronic devices may not be used in the exam.
  • In-person, closed book: The exam will take place on campus under invigilation. You may not refer to any physical materials or electronic devices during the exam. There may be times when a paper dictionary, for example, may be permitted in an otherwise closed book exam. Any exceptions will be specified by your department.

Your department will provide further guidance before your exams.

Overall assessment

Coursework Exam
100% 0%

Reassessment

Coursework Exam
100% 0%
Module supervisor and teaching staff
Dr Philip Reeves, email: preeves@essex.ac.uk.
Dr Phil Reeves,Dr Joaquin De Navascues, Dr Amanda Cavanagh
School Undergraduate Office, email: bsugoffice (Non essex users should add @essex.ac.uk to create the full email address)

 

Availability
Yes
No
No

External examiner

Dr Thomas Clarke
University of East Anglia
Senior lecturer/associate professor
Prof Jacqueline McCormack
Institute Technology Sligo
Vice President
Resources
Available via Moodle
Of 76 hours, 37 (48.7%) hours available to students:
39 hours not recorded due to service coverage or fault;
0 hours not recorded due to opt-out by lecturer(s), module, or event type.

 

Further information
Life Sciences (School of)

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